Borane;tetrahydrofuran → HCID 86635142、化合物
反応式
[N:1]([CH2:4][C:5]([C:7]1[CH:12]=[CH:11][C:10]([S:13][CH3:14])=[CH:9][CH:8]=1)=[O:6])=[N+:2]=[N-:3].B.C1COCC1>C1COCC1>[N:1]([CH2:4][CH:5]([C:7]1[CH:12]=[CH:11][C:10]([S:13][CH3:14])=[CH:9][CH:8]=1)[OH:6])=[N+:2]=[N-:3]参加物
4
反応条件
- 温度
- 0 °C
実験手順
A solution consisting of 2-azido-1-(4-methylsulfanyl-phenyl)-ethanone (1.69 g, 8.15 mmol) and THF (8.15 mL) was cooled to 0° C. before slowly adding BH3.THF (1.0 M solution, 8.15 ml) over 10 min. The resulting solution was stirred at 0° C. for 2 h. The reaction was quenched by slow addition of MeOH (10 mL) at 0° C., and then concentrating to dryness to yield the title compound (1.74 g, 100%).
後処理
- customThe reaction was quenched by slow addition of MeOH (10 mL) at 0° C.
- concentrationconcentrating to dryness
出典と根拠
- ORDレコード
- ord-fb1626e1d9964792a55b3792c5628738
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08598202B2
反応ノート
読み込み中…