2-Amino-1-(4-fluorophenyl)ethanone → 2-Amino-1-(4-fluorophenyl)ethan-1-ol

HRID 1908256

反応式

HRID 1908256 の反応式
[NH2:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=[O:4].[BH4-].[Na+]>CO>[NH2:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)[OH:4]

参加物

4

反応物 2

HCID 15811772-Amino-1-(4-fluorophenyl)ethanoneHCID 4311764Sodium borohydride

生成物 1

HCID 98272-Amino-1-(4-fluorophenyl)ethan-1-ol収率 100%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To a solution consisting of 2-amino-1-(4-fluoro-phenyl)-ethanone (150 mg, 0.9 mmol) and MeOH (5 mL) was added NaBH4 (97 mg, 2.6 mmol). The mixture was stirred at rt for 45 min and then concentrated to dryness. The residue was diluted with EtOAc and washed with a satd. NH4Cl solution before drying (Na2SO4), and concentrating to give 2-amino-1-(4-fluoro-phenyl)-ethanol (139 mg, 100%) which was used without further purification.

後処理

  1. concentrationconcentrated to dryness
  2. additionThe residue was diluted with EtOAc
  3. washwashed with a satd
  4. dry with materialNH4Cl solution before drying (Na2SO4)
  5. concentrationconcentrating

出典と根拠

ORDレコード
ord-3de15211aafd4142a970ccbc6622e103
出典データセット
uspto-grants-2013_12
特許番号
US08598202B2

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