2-Amino-1-(4-fluorophenyl)ethanone → 2-Amino-1-(4-fluorophenyl)ethan-1-ol
反応式
[NH2:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)=[O:4].[BH4-].[Na+]>CO>[NH2:1][CH2:2][CH:3]([C:5]1[CH:10]=[CH:9][C:8]([F:11])=[CH:7][CH:6]=1)[OH:4]参加物
4
実験手順
To a solution consisting of 2-amino-1-(4-fluoro-phenyl)-ethanone (150 mg, 0.9 mmol) and MeOH (5 mL) was added NaBH4 (97 mg, 2.6 mmol). The mixture was stirred at rt for 45 min and then concentrated to dryness. The residue was diluted with EtOAc and washed with a satd. NH4Cl solution before drying (Na2SO4), and concentrating to give 2-amino-1-(4-fluoro-phenyl)-ethanol (139 mg, 100%) which was used without further purification.
後処理
- concentrationconcentrated to dryness
- additionThe residue was diluted with EtOAc
- washwashed with a satd
- dry with materialNH4Cl solution before drying (Na2SO4)
- concentrationconcentrating
出典と根拠
- ORDレコード
- ord-3de15211aafd4142a970ccbc6622e103
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08598202B2
反応ノート
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