Sodium borohydride → 1-[2-(4-Chlorophenyl)thiazol-5-yl]ethanol
反応式
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[S:9][C:10]([C:13](=[O:15])[CH3:14])=[CH:11][N:12]=2)=[CH:4][CH:3]=1.[BH4-].[Na+]>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[S:9][C:10]([CH:13]([OH:15])[CH3:14])=[CH:11][N:12]=2)=[CH:6][CH:7]=1参加物
4
実験手順
To a suspension of 1-[2-(4-chlorophenyl)thiazol-5-yl]ethanone (5 g, 21 mmol) in methanol (100 ml) is added sodium borohydride (832 mg, 22 mmol) at room temperature. The reaction mixture is stirred at room temperature for 1 hour. The reaction mixture is quenched with saturated aqueous ammonium chloride solution (100 ml) and extracted with dichloromethane (2×150 ml). The combined organic extracts are dried over anhydrous magnesium sulfate, filtered and evaporated to dryness to give 1-[2-(4-chlorophenyl)thiazol-5-yl]ethanol (4.88 g).
後処理
- customThe reaction mixture is quenched with saturated aqueous ammonium chloride solution (100 ml)
- extractionextracted with dichloromethane (2×150 ml)
- dry with materialThe combined organic extracts are dried over anhydrous magnesium sulfate
- filtrationfiltered
- customevaporated to dryness
出典と根拠
- ORDレコード
- ord-22bf957ffe1b41f3b3882d53d0da55d7
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08598365B2
反応ノート
読み込み中…