N-bromobutanimide → 5-Bromo-4-chloro-7-methyl-7H-pyrrolo(2,3-d)pyrimidine
反応式
[Cl:1][C:2]1[C:3]2[CH:10]=[CH:9][N:8]([CH3:11])[C:4]=2[N:5]=[CH:6][N:7]=1.C1C(=O)N([Br:19])C(=O)C1>ClCCl>[Br:19][C:10]1[C:3]2[C:2]([Cl:1])=[N:7][CH:6]=[N:5][C:4]=2[N:8]([CH3:11])[CH:9]=1参加物
4
実験手順
To 4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (12.15 g, 72.5 mmol) in Dichloromethane (DCM) (200 mL) was added NBS (13.55 g, 76 mmol) portionwise, and the reaction mixture was stirred overnight at room temperature. The solvent was evaporated, and the solid was washed with water and dried to afford 5-bromo-4-chloro-7-methyl-7H-pyrrolo[2,3-d]pyrimidine (17 g) as an off-white solid.
後処理
- customThe solvent was evaporated
- washthe solid was washed with water
- customdried
出典と根拠
- ORDレコード
- ord-92316150a0524002954de3a3b1b347a4
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08598156B2
反応ノート
読み込み中…