Ethyl 3,4-dihydro-6,7-dimethoxy-1-isoquinolinecarboxylate → HCID 20202902、化合物
反応式
[CH2:1]([O:3][C:4]([C:6]1[C:15]2[C:10](=[CH:11][C:12]([O:18][CH3:19])=[C:13]([O:16][CH3:17])[CH:14]=2)[CH2:9][CH2:8][N:7]=1)=[O:5])[CH3:2]>[Pd]>[CH2:1]([O:3][C:4]([C:6]1[C:15]2[C:10](=[CH:11][C:12]([O:18][CH3:19])=[C:13]([O:16][CH3:17])[CH:14]=2)[CH:9]=[CH:8][N:7]=1)=[O:5])[CH3:2]参加物
3
実験手順
To a refluxing solution of 2.0 g (8.0 mmol) of 6,7-dimethoxy-3,4-dihydro-isoquinoline-1-carboxylic acid ethyl ester was added to 2.0 g of 10% Pd—C. After 12 h at reflux, the reaction mixture was cooled, filtered through celite, and evaporated under reduced pressure to provide 2.0 g (98%) of 6,7-dimethoxy-isoquinoline-1-carboxylic acid ethyl ester. LCMS: 262 (M+1)+.
後処理
- temperatureAfter 12 h at reflux
- temperaturethe reaction mixture was cooled
- filtrationfiltered through celite
- customevaporated under reduced pressure
出典と根拠
- ORDレコード
- ord-a007171d6d304e6ca7dd712626eb9388
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08598353B2
反応ノート
読み込み中…