Magnesium peroxide (Mg(O2)) → 4-Methyl-1-phenylisoquinoline

HRID 1910341

反応式

HRID 1910341 の反応式
[O-][O-].[Mg+2].[C:4]1([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[CH:13]([CH3:20])[CH2:12][N:11]=2)[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1>C1C=CC=CC=1>[C:4]1([C:10]2[C:19]3[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=3)[C:13]([CH3:20])=[CH:12][N:11]=2)[CH:5]=[CH:6][CH:7]=[CH:8][CH:9]=1

参加物

4

反応物 2

HCID 61745Magnesium peroxide (Mg(O2))HCID 131435804-Methyl-1-phenyl-3,4-dihydroisoquinoline

生成物 1

HCID 128434954-Methyl-1-phenylisoquinoline収率 42.5%

試薬・触媒・溶媒 1

HCID 241Benzene溶媒

実験手順

To a suspension of activated magnesium dioxide (270 g, 0.132 mol) in 550 mL of benzene was added 1-phenyl-4-methyl-3,4-dihydroisoquinoline (29.0 g, 0.131 mol) with stirring. The reaction mixture was heated at reflux for 16 hours. The magnesium dioxide was removed by vacuum filtration and washed with methylene chloride. Evaporation of the solvent yielded 12.2 g (42%) of pure yellow crystals of 1-phenyl-4-methylisoquinoline.

後処理

  1. temperatureThe reaction mixture was heated
  2. temperatureat reflux for 16 hours
  3. customThe magnesium dioxide was removed by vacuum filtration
  4. washwashed with methylene chloride
  5. customEvaporation of the solvent

出典と根拠

ORDレコード
ord-713ee148d584444f812fc7d9b29f8c64
出典データセット
uspto-grants-2013_12
特許番号
US08603645B2

関連ノート

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