化工社化工社 化学情報印刷レポート · 研究参考用
Magnesium peroxide (Mg(O2)) → 4-Methyl-1-phenylisoquinoline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Magnesium peroxide (Mg(O2)) | HCID 61745 | — |
| 反応物 | 4-Methyl-1-phenyl-3,4-dihydroisoquinoline | HCID 13143580 | — |
| 溶媒 | Benzene | HCID 241 | — |
| 生成物 | 4-Methyl-1-phenylisoquinoline | HCID 12843495 | 42.5% |
反応手順
To a suspension of activated magnesium dioxide (270 g, 0.132 mol) in 550 mL of benzene was added 1-phenyl-4-methyl-3,4-dihydroisoquinoline (29.0 g, 0.131 mol) with stirring. The reaction mixture was heated at reflux for 16 hours. The magnesium dioxide was removed by vacuum filtration and washed with methylene chloride. Evaporation of the solvent yielded 12.2 g (42%) of pure yellow crystals of 1-phenyl-4-methylisoquinoline.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08603645B2 |
| 出典データセット | uspto-grants-2013_12 |
| ORD ID | ord-713ee148d584444f812fc7d9b29f8c64 |
| 出典メモ | uspto-grants-2013_12 |