反应详情

To a suspension of activated magnesium dioxide (270 g, 0.132 mol) in 550 mL of benzene was added 1-phenyl-4-methyl-3,4-dihydroisoquinoline (29.0 g, 0.131 mol) with stirring. The reaction mixture was heated at reflux for 16 hours. The magnesium dioxide was removed by vacuum filtration and washed with methylene chloride. Evaporation of the solvent yielded 12.2 g (42%) of pure yellow crystals of 1-phenyl-4-methylisoquinoline.

1. temperatureThe reaction mixture was heated
2. temperatureat reflux for 16 hours
3. customThe magnesium dioxide was removed by vacuum filtration
4. washwashed with methylene chloride
5. customEvaporation of the solvent