tert-Butyl chloroacetate → HCID 70673630、化合物

HRID 1910501ノート

反応式

HRID 1910501 の反応式
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([C:9]([O:11][CH:12]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1)=[O:10])[CH2:2]2.[Cl:27][CH2:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30]>C(#N)C>[Cl-:27].[F:26][C:22]1[CH:21]=[C:20]([CH:12]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=2)[O:11][C:9]([CH:3]2[CH:4]3[CH2:5][CH2:6][N+:1]([CH2:28][C:29]([O:31][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:30])([CH2:8][CH2:7]3)[CH2:2]2)=[O:10])[CH:25]=[CH:24][CH:23]=1

参加物

4

反応物 2

HCID 66052tert-Butyl chloroacetate2 回HCID 70925896Bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate

生成物 1

HCID 70673630HCID 70673630、化合物収率 41.7%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate (70 mg, 0.20 mmol, prepared as in example 4) and tert-butyl 2-chloroacetate (31 μl, 0.21 mmol) were dissolved in acetonitrile (3 ml) and stirred at room temperature overnight. Tert-butyl 2-chloroacetate (28 μl, 0.20 mmol) was added again, and the mixture was stirred for additional 24 hours. Acetonitrile was evaporated, and the resulting crude compound was triturated from Et2O and filtered to obtain 3-((bis(3-fluorophenyl)methoxy)carbonyl)-1-(2-tert-butoxy-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane chloride (42.4 mg, racemic mixture).

後処理

  1. stirringthe mixture was stirred for additional 24 hours
  2. customAcetonitrile was evaporated
  3. customthe resulting crude compound was triturated from Et2O
  4. filtrationfiltered

出典と根拠

ORDレコード
ord-3d9eb796f2da440c93358be503ab396d
出典データセット
uspto-grants-2013_12
特許番号
US08604015B2

反応ノート

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