Ethyl 5-(2-bromoacetyl)isoxazole-3-carboxylate → HCID 86672940、化合物

HRID 1910502

反応式

HRID 1910502 の反応式
[N:1]12[CH2:8][CH2:7][CH:4]([CH2:5][CH2:6]1)[CH:3]([C:9]([O:11][CH:12]([C:20]1[CH:25]=[CH:24][CH:23]=[C:22]([F:26])[CH:21]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=1)=[O:10])[CH2:2]2.[Br:27][CH2:28][C:29]([C:31]1[O:35][N:34]=[C:33]([C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH:32]=1)=[O:30]>C(#N)C>[Br-:27].[F:26][C:22]1[CH:21]=[C:20]([CH:12]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([F:19])[CH:14]=2)[O:11][C:9]([CH:3]2[CH:4]3[CH2:5][CH2:6][N+:1]([CH2:28][C:29]([C:31]4[O:35][N:34]=[C:33]([C:36]([O:38][CH2:39][CH3:40])=[O:37])[CH:32]=4)=[O:30])([CH2:8][CH2:7]3)[CH2:2]2)=[O:10])[CH:25]=[CH:24][CH:23]=1

参加物

4

反応物 2

HCID 2736373Ethyl 5-(2-bromoacetyl)isoxazole-3-carboxylateHCID 70925896Bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate

生成物 1

HCID 86672940HCID 86672940、化合物収率 17.5%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

Bis(3-fluorophenyl)methyl quinuclidine-3-carboxylate (86 mg, 0.24 mmol, prepared as in example 4) and ethyl 5-(2-bromoacetyl)isoxazole-3-carboxylate (69.4 mg, 0.26 mmol) were dissolved in acetonitrile (3 ml) and stirred at room temperature overnight. The precipitated was recovered by suction filtration to obtain 3-((bis(3-fluorophenyl)methoxy)carbonyl)-1-(2-(3-(ethoxycarbonyl)isoxazol-5-yl)-2-oxoethyl)-1-azoniabicyclo[2.2.2]octane bromide (26 mg, racemic mixture).

後処理

  1. filtrationThe precipitated was recovered by suction filtration

出典と根拠

ORDレコード
ord-9ef1597c26f24f4ea802ba9f803442c6
出典データセット
uspto-grants-2013_12
特許番号
US08604015B2

関連ノート

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