Nitric Acid → 4-(4-Nitrophenyl)-1,3-oxazole

HRID 1910746

反応式

HRID 1910746 の反応式
[C:1]1([C:7]2[N:8]=[CH:9][O:10][CH:11]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[N+:12]([O-])([OH:14])=[O:13]>S(=O)(=O)(O)O>[N+:12]([C:4]1[CH:3]=[CH:2][C:1]([C:7]2[N:8]=[CH:9][O:10][CH:11]=2)=[CH:6][CH:5]=1)([O-:14])=[O:13]

参加物

4

反応物 2

HCID 944Nitric AcidHCID 5892794-Phenyl-1,3-oxazole

生成物 1

HCID 145677974-(4-Nitrophenyl)-1,3-oxazole収率 42%

試薬・触媒・溶媒 1

HCID 1118Sulfuric Acid溶媒

実験手順

4-Phenyloxazole (1 g, 6.89 mmol) was dissolved in concentrated sulfuric acid (5 mL) at 0° C. A cold solution of nitrating mixture (prepared by adding 3 mL conc. nitric acid to 5 mL of ice-cold conc. sulfuric acid) was added over 10 minutes. The mixture was allowed to warm to r.t. and stirred for 1 h. The resulting solution was poured into ice-cold water giving a white precipitate, which was filtered and washed thoroughly with water. The solid was dissolved in DCM and washed with water then brine. The organic phase was dried over sodium sulfate and concentrated to yield 4-(4-nitro-phenyl)-oxazole (550 mg, 42%) as a white solid.

後処理

  1. additionwas added over 10 minutes
  2. additionThe resulting solution was poured into ice-cold water giving a white precipitate, which
  3. filtrationwas filtered
  4. washwashed thoroughly with water
  5. dissolutionThe solid was dissolved in DCM
  6. washwashed with water
  7. dry with materialThe organic phase was dried over sodium sulfate
  8. concentrationconcentrated

出典と根拠

ORDレコード
ord-ffd008174f1c460f823e039a0141c6bd
出典データセット
uspto-grants-2013_12
特許番号
US08604029B2

関連ノート

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