Formamidine acetate → HCID 178518231、化合物
反応式
[NH2:1][N:2]1[CH:6]=[CH:5][N:4]=[C:3]1[C:7]([O:9]CC)=O.C(O)(=O)C.[CH:16](N)=[NH:17]>CCO>[CH:5]1[N:4]=[C:3]2[C:7]([N:17]=[CH:16][NH:1][N:2]2[CH:6]=1)=[O:9]参加物
4
実験手順
A mixture of ethyl 1-amino-1H-imidazole-2-carboxylate (C-4) (800 mg, 5.16 mmol, 1.0 eq) and formamidine acetate (2.68 g, 25.78 mmol, 5.0 eq) in EtOH (100 mL) is stirred at reflux overnight. The resulting mixture is cooled to RT. The solid is collected by filtration, rinsed with EtOH (3×2 mL) and petroleum ether (2 mL×3), and then dried in vacuo to afford the product, imidazo[1,2-f][1,2,4]triazin-4-ol (C-5).
後処理
- temperatureat reflux overnight
- filtrationThe solid is collected by filtration
- washrinsed with EtOH (3×2 mL) and petroleum ether (2 mL×3)
- customdried in vacuo
出典と根拠
- ORDレコード
- ord-1dae880d81a544f488751c7688749de1
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08604032B2
反応ノート
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