Hydrochloric Acid → HCID 68715953、化合物

HRID 1911519ノート

反応式

HRID 1911519 の反応式
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2([CH3:16])[NH:13]C(=O)N[C:10]2=[O:15])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl.[OH-:18].[Na+]>>[ClH:1].[NH2:13][C:9]([C:4]1[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=1)([CH3:16])[C:10]([OH:18])=[O:15]

参加物

4

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 300965552715-57-8

生成物 1

HCID 68715953HCID 68715953、化合物収率 27%

実験手順

A solution of 5-(3,4-dichloro-phenyl)-5-methyl-imidazolidine-2,4-dione (3.0 g; CAS 52715-57-8) in 3N NaOH (30 ml) was refluxed overnight. The reaction mixture was cooled to 0°, then brought to pH 1 by dropwise addition of concentrated HCl. The resulting white slurry was filtered. The solid was washed extensively with H2O, dried in the vacuum, resuspended in EtOH (25 ml), collected by filtration, washed with EtOH and diethylether and dried in the vacuum to give (RS)-2-amino-2-(3,4-dichloro-phenyl)-propionic acid hydrochloride (1.35 g, 27%) as off white solid.

後処理

  1. temperatureThe reaction mixture was cooled to 0°
  2. filtrationThe resulting white slurry was filtered
  3. washThe solid was washed extensively with H2O
  4. customdried in the vacuum
  5. filtrationcollected by filtration
  6. washwashed with EtOH and diethylether
  7. customdried in the vacuum

出典と根拠

ORDレコード
ord-6fdcbbd45e8e4b098cc62c2513c6b16f
出典データセット
uspto-grants-2013_12
特許番号
US08604061B2

反応ノート

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