3-Isobutyl-1-cyclobutenecarboxylic acid → cis-3-Isobutylcyclobutane carboxylic acid
反応式
[CH2:1]([CH:5]1[CH2:8][C:7]([C:9]([OH:11])=[O:10])=[CH:6]1)[CH:2]([CH3:4])[CH3:3]>[Rh].O1CCCC1>[CH2:1]([CH:5]1[CH2:6][CH:7]([C:9]([OH:11])=[O:10])[CH2:8]1)[CH:2]([CH3:4])[CH3:3]参加物
4
実験手順
3-Isobutyl-1-cyclobutenecarboxylic acid (188 g) and tetrahydrofuran (2000 mL) were mixed. To the mixture was added 5 w/w % rhodium on activated carbon (5.64 g). The resulting mixture was stirred at RT for 7 hr under hydrogen atmosphere (1 atm). The 5 w/w % rhodium on activated carbon was filtered off and the filtrate was concentrated in vacuo to give the title compound (134.06 g) as a crude product.
後処理
- filtrationwas filtered off
- concentrationthe filtrate was concentrated in vacuo
出典と根拠
- ORDレコード
- ord-a85d21ab2ffd4abcab37a2ea848017fd
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08604069B2
反応ノート
読み込み中…