Sodium Hydroxide → 4-(2-Chloro-4-methylphenylcarbamoyl)-3-{4-cyclopropyl-5-[3-(2-ethylbutyl)cyclobutyl]isoxazol-3-yl}butanoate sodium
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([CH2:12][CH:13]([C:18]1[C:22]([CH:23]2[CH2:25][CH2:24]2)=[C:21]([CH:26]2[CH2:29][CH:28]([CH2:30][CH:31]([CH2:34][CH3:35])[CH2:32][CH3:33])[CH2:27]2)[O:20][N:19]=1)[CH2:14][C:15]([OH:17])=[O:16])=[O:11].[OH-].[Na+:37]>C(O)C>[Na+:37].[Cl:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[NH:9][C:10]([CH2:12][CH:13]([C:18]1[C:22]([CH:23]2[CH2:24][CH2:25]2)=[C:21]([CH:26]2[CH2:27][CH:28]([CH2:30][CH:31]([CH2:34][CH3:35])[CH2:32][CH3:33])[CH2:29]2)[O:20][N:19]=1)[CH2:14][C:15]([O-:17])=[O:16])=[O:11]参加物
4
反応物 2
生成物 1
試薬・触媒・溶媒 1
実験手順
4-(2-Chloro-4-methylphenylcarbamoyl)-3-{4-cyclopropyl-5-[3-(2-ethylbutyl)cyclobutyl]isoxazol-3-yl}butanoic acid (28.9 mg) and ethanol (1 mL) were mixed. To the mixture was added aqueous 1 N sodium hydroxide (0.0577 mL) at ice temperature. The mixture was stirred at ice temperature 20 min., and then the solvent was evaporated to give the title compound (30.4 mg) as a crude product.