Thionyl Chloride → HCID 86665150、化合物

HRID 1912510ノート

反応式

HRID 1912510 の反応式
[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10](O)=[O:11].S(Cl)([Cl:16])=O>CN(C)C=O>[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10]([Cl:16])=[O:11]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 671611162-((1S,2S,5S)-6,6-Dimethylbicyclo[3.1.1]heptan-2-yl)acetic acid

生成物 1

HCID 86665150HCID 86665150、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
22 °C

実験手順

To a mixture of Example 1B (300 mg, 1.65 mmol) and thionyl chloride (901 μL, 12.4 mmol) was added a drop of dimethylformamide. The reaction was stirred at about 22° C. for 2 hours. The excess thionyl chloride was evaporated and the residue was dried under vacuum to afford the title compound.

後処理

  1. customThe excess thionyl chloride was evaporated
  2. customthe residue was dried under vacuum

出典と根拠

ORDレコード
ord-4406a30cc25e48f1883537dfb684f406
出典データセット
uspto-grants-2013_12
特許番号
US08609674B2

反応ノート

読み込み中…