Adenine → 9-(4-nitro-phenyl)-9H-purin-6-ylamine

HRID 1912859

反応式

HRID 1912859 の反応式
[N:1]1[C:9]([NH2:10])=[C:8]2[C:4]([N:5]=[CH:6][NH:7]2)=[N:3][CH:2]=1.CC(C)([O-])C.[K+].F[C:18]1[CH:23]=[CH:22][C:21]([N+:24]([O-:26])=[O:25])=[CH:20][CH:19]=1>CS(C)=O.O>[N+:24]([C:21]1[CH:22]=[CH:23][C:18]([N:5]2[CH:6]=[N:7][C:8]3[C:4]2=[N:3][CH:2]=[N:1][C:9]=3[NH2:10])=[CH:19][CH:20]=1)([O-:26])=[O:25]

参加物

6

反応物 3

HCID 190AdenineHCID 9590p-FluoronitrobenzeneHCID 23665647Potassium tert-butoxide

生成物 1

HCID 3090939-(4-nitro-phenyl)-9H-purin-6-ylamine収率 93.7%

試薬・触媒・溶媒 2

HCID 679Dimethyl Sulfoxide溶媒HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

In 100 ml of dimethyl sulfoxide, 4.05 g (30.0 mmol) of adenine was dissolved, and 3.5 g (31.0 mmol) of potassium tert-butoxide and 5.0 g (35.0 mmol) of 4-fluoronitrobenzene were added thereto, and the mixture solution was stirred at 80° C. for three hours. The solution was diluted with 200 mL of water and the precipitate formed was collected by filtration, washed with 100 mL of water and 30 mL of methanol in the order named and vacuum dried to obtain 7.2 g (84%) of a target product as a yellow solid.

後処理

  1. customthe precipitate formed
  2. filtrationwas collected by filtration
  3. washwashed with 100 mL of water and 30 mL of methanol in the order
  4. customvacuum dried

出典と根拠

ORDレコード
ord-fc675b0af2b8458d801a87703d3d2378
出典データセット
uspto-grants-2013_12
特許番号
US08609656B2

関連ノート

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