Thionyl Chloride → HCID 86665150、化合物

HRID 1912894ノート

反応式

HRID 1912894 の反応式
[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10](O)=[O:11].S(Cl)([Cl:16])=O>CN(C)C=O>[CH3:1][C:2]1([CH3:13])[C@H:7]2[CH2:8][C@@H:3]1[CH2:4][CH2:5][C@H:6]2[CH2:9][C:10]([Cl:16])=[O:11]

参加物

4

反応物 2

HCID 24386Thionyl ChlorideHCID 671611162-((1S,2S,5S)-6,6-Dimethylbicyclo[3.1.1]heptan-2-yl)acetic acid

生成物 1

HCID 86665150HCID 86665150、化合物

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
22 °C

実験手順

To a mixture of the product from Example 4B (300 mg, 1.65 mmol) and thionyl chloride (901 μL, 12.4 mmol) was added a drop of dimethylformamide. The reaction was stirred at 22° C. for 2 hours. The excess of thionyl chloride was evaporated and the residue was dried under vacuum to afford the title compound.

後処理

  1. customThe excess of thionyl chloride was evaporated
  2. customthe residue was dried under vacuum

出典と根拠

ORDレコード
ord-725e7c30827546548599d3f286001c5d
出典データセット
uspto-grants-2013_12
特許番号
US08609669B2

反応ノート

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