Thionyl Chloride → HCID 86665181、化合物

HRID 1912947ノート

反応式

HRID 1912947 の反応式
[CH:1]1([S:6][CH2:7][C:8]([OH:10])=O)[CH2:5][CH2:4][CH2:3][CH2:2]1.S(Cl)([Cl:13])=O>>[CH:1]1([S:6][CH2:7][C:8]([Cl:13])=[O:10])[CH2:5][CH2:4][CH2:3][CH2:2]1

参加物

3

反応物 2

HCID 24386Thionyl ChlorideHCID 15728315(Cyclopentylsulfanyl)acetic acid

生成物 1

HCID 86665181HCID 86665181、化合物

反応条件

温度
70 °C

実験手順

The product from Example 143B (6.56 g) was combined with thionyl chloride (50 mL, 685 mmol) and the reaction mixture was heated at 70° C. for 2 hours. The reaction mixture was concentrated under vacuum, and the residue was dissolved in CHCl3 (50 mL) and concentrated again to remove excess thionyl chloride. The residue was distilled under vacuum (air bath 100-110° C./˜10 mm) to provide the title compound, used directly for the next step.

後処理

  1. concentrationThe reaction mixture was concentrated under vacuum
  2. dissolutionthe residue was dissolved in CHCl3 (50 mL)
  3. concentrationconcentrated again
  4. customto remove excess thionyl chloride
  5. distillationThe residue was distilled under vacuum (air bath 100-110° C./˜10 mm)

出典と根拠

ORDレコード
ord-ba22d4f86d254542b5d9526c68ae0697
出典データセット
uspto-grants-2013_12
特許番号
US08609669B2

反応ノート

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