(+/-)-ethyl 2-(1-methyl-2,3-dihydro-1H-inden-1-yl)acetate → ethyl 2-(2,3-dihydro-1H-inden-1-yl)acetate

HRID 1912970ノート

反応式

HRID 1912970 の反応式
C[C:2]1([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1>CCO.[Pd]>[CH:2]1([CH2:11][C:12]([O:14][CH2:15][CH3:16])=[O:13])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH2:4][CH2:3]1

参加物

4

反応物 1

HCID 86665180(+/-)-ethyl 2-(1-methyl-2,3-dihydro-1H-inden-1-yl)acetate

生成物 1

HCID 12322855ethyl 2-(2,3-dihydro-1H-inden-1-yl)acetate収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

To a mixture of products from Example 131A (0.47 g, 2.3 mmol) in EtOH (20 mL) was added Pd/C (49.5 mg, 0.046 mmol). The reaction mixture was stirred under H2 atmosphere using a balloon until the starting material completely consumed. The mixture was filtered and concentrated under reduced pressure to obtain 0.47 g of the title compound. MS (DCI/NH3) m/z 222 (M+NH4)+.

後処理

  1. customcompletely consumed
  2. filtrationThe mixture was filtered
  3. concentrationconcentrated under reduced pressure

出典と根拠

ORDレコード
ord-eed5562249a14ebfab76c882ef6eb241
出典データセット
uspto-grants-2013_12
特許番号
US08609669B2

反応ノート

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