HCID 12301740、化合物 → Pyrazolo[1,5-a]pyridine-2-acetic acid, 4,5,6,7-tetrahydro-3-(methoxycarbonyl)-, methyl ester
反応式
[CH3:1][O:2][C:3](=[O:18])[CH2:4][C:5]1[C:13]([C:14]([O:16][CH3:17])=[O:15])=[C:8]2[CH:9]=[CH:10][CH:11]=[CH:12][N:7]2[N:6]=1>CO.[Pd]>[CH3:1][O:2][C:3](=[O:18])[CH2:4][C:5]1[C:13]([C:14]([O:16][CH3:17])=[O:15])=[C:8]2[CH2:9][CH2:10][CH2:11][CH2:12][N:7]2[N:6]=1参加物
4
実験手順
Methyl 2-(2-methoxy-2-oxoethyl)pyrazolo[1,5-a]pyridine-3-carboxylate (42.0 mg, 0.17 mmol), as prepared according to the procedure described in Stefan Löber, S.; Hübner, H.; Gmeiner B.; Biorg. Med. Chem. Lett. 12(17), 2377 (2002), was dissolved in MeOH (5 mL) and was hydrogenated on an H-Cube® hydrogenation apparatus with 10% Pd/C at 40° C. for 1 hour. The methanol solution was removed in vacuo to afford methyl 2-(2-methoxy-2-oxoethyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine-3-carboxylate (39 mg, 91%), which was used directly in the next step without further purification.