HCID 178465384、化合物 → HCID 178463402、化合物
反応式
C(OC(=O)[NH:10][CH:11]([C:13]1[NH:14][CH:15]=[C:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[N:17]=1)[CH3:12])C1C=CC=CC=1>CO.[Pd]>[C:18]1([C:16]2[N:17]=[C:13]([CH:11]([NH2:10])[CH3:12])[NH:14][CH:15]=2)[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=1参加物
4
実験手順
To a solution of [1-(4-phenyl-1H-imidazol-2-yl)-ethyl]-carbamic acid benzyl ester (1.5 g, 4.67 mmol) in methanol (25 mL) was added 10% palladium on carbon (0.16 g). The mixture was shaken in a hydrogenation apparatus at rt under a hydrogen atmosphere (10 psi) for 8 h. Filtration followed by evaporation to dryness under reduced pressure gave the crude product 1-(4-Phenyl-1H-imidazol-2-yl)-ethylamine (0.88 g, 100%). 1H NMR (300 MHz, CDCl3): δ 1.53 (3H, d), 4.33 (1H, q), 7.23 (3H, m), 7.37 (2H, m), 7.67 (2H, m). MS (ES+): 188.1 (38%).