Hydrochloric Acid → N-allyl-L-aspartic acid di-tert-butyl ester hydrochloride

HRID 1913589ノート

反応式

HRID 1913589 の反応式
[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:3])[CH3:2].O.[ClH:22]>C(#N)C>[ClH:22].[C:1]([O:5][C:6](=[O:20])[C@H:7]([CH2:12][C:13]([O:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[O:14])[NH:8][CH2:9][CH:10]=[CH2:11])([CH3:4])([CH3:2])[CH3:3]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 962WaterHCID 86673330N-allyl-L-aspartic acid di-tert-butyl ester

生成物 1

HCID 86673331N-allyl-L-aspartic acid di-tert-butyl ester hydrochloride収率 47%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

The obtained N-allyl-L-aspartic acid di-tert-butyl ester was dissolved in acetonitrile (10 mL), and water (17 mL) and 1N hydrochloric acid (1.8 mL, 1.8 mmol) were added. The solution was concentrated under reduced pressure and freeze-dried to give the title compound (0.54 g, 1.7 mmol, 47%).

後処理

  1. concentrationThe solution was concentrated under reduced pressure
  2. customfreeze-dried

出典と根拠

ORDレコード
ord-9519987bdb0b4d458076c836529d423d
出典データセット
uspto-grants-2013_12
特許番号
US08609715B2

反応ノート

読み込み中…