4-(Pentafluoroethyl)-2-nitrophenol → 2-Amino-4-(pentafluoroethyl)phenol
反応式
[F:1][C:2]([F:17])([C:7]1[CH:12]=[CH:11][C:10]([OH:13])=[C:9]([N+:14]([O-])=O)[CH:8]=1)[C:3]([F:6])([F:5])[F:4].[H][H]>[Pd].C(OCC)(=O)C>[NH2:14][C:9]1[CH:8]=[C:7]([C:2]([F:1])([F:17])[C:3]([F:4])([F:5])[F:6])[CH:12]=[CH:11][C:10]=1[OH:13]参加物
5
実験手順
A mixture of 1.38 g of 4-(pentafluoroethyl)-2-nitrophenol, 15 ml of ethyl acetate and 0.15 g of 5% palladium on carbon was stirred under about one atmosphere of hydrogen at room temperature for four hours. The reaction mixture was filtered through Celite™. The filtrate was concentrated under reduced pressure. The residue was washed with hexane to give 1.02 g of 2-amino-4-(pentafluoroethyl)phenol.
後処理
- filtrationThe reaction mixture was filtered through Celite™
- concentrationThe filtrate was concentrated under reduced pressure
- washThe residue was washed with hexane
出典と根拠
- ORDレコード
- ord-51a35de311fe404aa2baca557fa88412
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08609705B2
反応ノート
読み込み中…