Sodium Hydroxide → HCID 2402152、化合物
反応式
C[O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][C:7]([O:10][CH2:11][C@@H:12]2[CH2:16][CH2:15][CH2:14][O:13]2)=[CH:6][CH:5]=1.[OH-].[Na+]>CO>[O:13]1[CH2:14][CH2:15][CH2:16][C@H:12]1[CH2:11][O:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([OH:17])=[O:2])=[CH:5][CH:6]=1参加物
4
実験手順
A mixture of 4-[(S)-1-(tetrahydrofuran-2-yl)methoxy]benzoic acid methyl ester (9.8 g), sodium hydroxide solution (2 N; 80 ml) and MeOH (300 ml) was stirred for 12 hours. Organic volatile fractions were removed on a rotary evaporator. The remaining aqueous phase was extracted with methyl tert-butyl ether (MTBE) and then acidified with concentrated hydrochloric acid. The resulting precipitate was filtered off and dried. The product was thus obtained with the molecular weight of 222.24 (C12H14O4); MS (ESI): 223 (M+H+).
後処理
- customOrganic volatile fractions were removed on a rotary evaporator
- extractionThe remaining aqueous phase was extracted with methyl tert-butyl ether (MTBE)
- filtrationThe resulting precipitate was filtered off
- customdried
- customThe product was thus obtained with the molecular weight of 222.24 (C12H14O4)
出典と根拠
- ORDレコード
- ord-4126719d81d4429d8a1149ee484cacf9
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08609731B2
反応ノート
読み込み中…