N-((S)-6-Pyridin-3-yl-1,2,3,4-tetrahydronaphthalen-2-yl)-4-[(S)-1-(tetrahydrofuran-2-yl)methoxy]benzamide → N-((S)-6-Piperidin-3-yl-1,2,3,4-tetrahydronaphthalen-2-yl)-4-[(S)-1-(tetrahydrofuran-2-yl)methoxy]benzamide
反応式
[N:1]1[CH:6]=[CH:5][CH:4]=[C:3]([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[CH2:13][C@@H:12]([NH:17][C:18](=[O:32])[C:19]2[CH:24]=[CH:23][C:22]([O:25][CH2:26][C@@H:27]4[CH2:31][CH2:30][CH2:29][O:28]4)=[CH:21][CH:20]=2)[CH2:11][CH2:10]3)[CH:2]=1>[Pt](=O)=O.C(O)(=O)C>[NH:1]1[CH2:6][CH2:5][CH2:4][CH:3]([C:7]2[CH:8]=[C:9]3[C:14](=[CH:15][CH:16]=2)[CH2:13][C@@H:12]([NH:17][C:18](=[O:32])[C:19]2[CH:20]=[CH:21][C:22]([O:25][CH2:26][C@@H:27]4[CH2:31][CH2:30][CH2:29][O:28]4)=[CH:23][CH:24]=2)[CH2:11][CH2:10]3)[CH2:2]1参加物
4
反応物 1
生成物 1
試薬・触媒・溶媒 2
実験手順
A mixture of N-((S)-6-pyridin-3-yl-1,2,3,4-tetrahydronaphthalen-2-yl)-4-[(S)-1-(tetrahydrofuran-2-yl)methoxy]benzamide (0.60 g), glacial acetic acid (30 ml) and platinum(IV) oxide (0.10 g) was stirred vigorously under a hydrogen atmosphere (balloon) for 12 hours. The catalyst was filtered off with suction and the filtrate was concentrated. The product was thus obtained with the molecular weight of 434.58 (C27H34N2O3); MS (ESI): 435 (M+H+).