p-Toluenesulfonic acid → Sorafenib Tosylate

HRID 1913896

反応式

HRID 1913896 の反応式
[CH3:1][NH:2][C:3]([C:5]1[CH:6]=[C:7]([O:11][C:12]2[CH:13]=[CH:14][C:15]([NH:18][C:19]([NH:21][C:22]3[CH:23]=[CH:24][C:25]([Cl:32])=[C:26]([C:28]([F:31])([F:30])[F:29])[CH:27]=3)=[O:20])=[CH:16][CH:17]=2)[CH:8]=[CH:9][N:10]=1)=[O:4].[C:33]1([CH3:43])[CH:38]=[CH:37][C:36]([S:39]([OH:42])(=[O:41])=[O:40])=[CH:35][CH:34]=1>O>[CH3:43][C:33]1[CH:38]=[CH:37][C:36]([S:39]([OH:42])(=[O:41])=[O:40])=[CH:35][CH:34]=1.[CH3:1][NH:2][C:3]([C:5]1[CH:6]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([NH:18][C:19]([NH:21][C:22]3[CH:23]=[CH:24][C:25]([Cl:32])=[C:26]([C:28]([F:31])([F:29])[F:30])[CH:27]=3)=[O:20])=[CH:14][CH:13]=2)[CH:8]=[CH:9][N:10]=1)=[O:4]

参加物

4

反応物 2

HCID 6101p-Toluenesulfonic acidHCID 216239Sorafenib

生成物 1

HCID 406563Sorafenib Tosylate収率 44%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

Sorafenib free base (2 g) was added to a saturated solution of p-toluenesulphonic acid (22.0 g) in water (10 mL). The reaction mixture was stirred at about 30° C. to about 32° C. for about 12 hours. The reaction mixture was filtered. The solid material was washed with acetone (2×10 mL) and dried under reduced pressure at about 50° C. for about 12 hours to obtain sorafenib tosylate.

後処理

  1. filtrationThe reaction mixture was filtered
  2. washThe solid material was washed with acetone (2×10 mL)
  3. customdried under reduced pressure at about 50° C. for about 12 hours

出典と根拠

ORDレコード
ord-f60d47c575f241c2be49ddab6998e013
出典データセット
uspto-grants-2013_12
特許番号
US08609854B2

関連ノート

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