関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | p-Toluenesulfonic acid | HCID 6101 | — |
| 反応物 | Sorafenib | HCID 216239 | — |
| 溶媒 | Water | HCID 962 | — |
| 生成物 | Sorafenib Tosylate | HCID 406563 | 71.6% |
反応手順
Sorafenib free base (2 g) was added to a solution of p-toluenesulphonic acid (1.63 g) in water (10 mL). The reaction mixture was stirred at about 55° C. for about 18 hours. The reaction mixture was filtered and dried under reduced pressure at about 50° C. for about 10 hours to 12 hours to obtain sorafenib tosylate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08609854B2 |
|---|
| 出典データセット | uspto-grants-2013_12 |
|---|
| ORD ID | ord-ffddedb5c1034e76855f6be048ae0b2d |
|---|
| 出典メモ | uspto-grants-2013_12 |
|---|
