反应详情

温度

55 °C

Sorafenib free base (2 g) was added to a solution of p-toluenesulphonic acid (1.63 g) in water (10 mL). The reaction mixture was stirred at about 55° C. for about 18 hours. The reaction mixture was filtered and dried under reduced pressure at about 50° C. for about 10 hours to 12 hours to obtain sorafenib tosylate.

1. filtrationThe reaction mixture was filtered
2. customdried under reduced pressure at about 50° C. for about 10 hours to 12 hours