Chloroacetyl chloride → 2-chloro-N-methyl-N-octylacetamide

HRID 1914053

反応式

HRID 1914053 の反応式
[Cl:1][CH2:2][C:3](Cl)=[O:4].[CH3:6][NH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15]>C(OCC)C>[CH3:6][N:7]([CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH3:15])[C:3](=[O:4])[CH2:2][Cl:1]

参加物

4

反応物 2

HCID 6577Chloroacetyl chlorideHCID 75538Octylmethylamine

生成物 1

HCID 856901342-chloro-N-methyl-N-octylacetamide収率 66.4%

試薬・触媒・溶媒 1

HCID 3283Diethyl Ether溶媒2 回

実験手順

Chloroacetyl chloride in diethylether was added dropwise to N-methyloctylamine in diethylether at −2° C. The organic solution was returned to room temperature, followed by stirring for 3 hours. The resulting solution was successively washed with an aqueous 1 mol/L hydrochloric acid solution and water, and then dried over anhydrous sodium sulfate. After removal the solvent under vacuum, the residue was purified by silica gel column chromatography (hexane:ethyl acetate=23:2) to give N-methyl-N-octyl-chloroacetamide (yield: 66.4%).

後処理

  1. customwas returned to room temperature
  2. washThe resulting solution was successively washed with an aqueous 1 mol/L hydrochloric acid solution and water
  3. dry with materialdried over anhydrous sodium sulfate
  4. customAfter removal the solvent under vacuum
  5. customthe residue was purified by silica gel column chromatography (hexane:ethyl acetate=23:2)

出典と根拠

ORDレコード
ord-7fa9884aa2974055beceb669fdc98013
出典データセット
uspto-grants-2013_12
特許番号
US08609898B2

関連ノート

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