5-Pyridin-4-yl-thiophene-3-carboxylic acid ethyl ester → 5-Pyridin-4-yl-thiophene-3-carboxylic acid
反応式
C([O:3][C:4]([C:6]1[CH:10]=[C:9]([C:11]2[CH:16]=[CH:15][N:14]=[CH:13][CH:12]=2)[S:8][CH:7]=1)=[O:5])C>[OH-].[Na+]>[N:14]1[CH:13]=[CH:12][C:11]([C:9]2[S:8][CH:7]=[C:6]([C:4]([OH:5])=[O:3])[CH:10]=2)=[CH:16][CH:15]=1参加物
3
反応条件
- 温度
- 130 °C
実験手順
5-Pyridin-4-yl-thiophene-3-carboxylic acid ethyl ester (1.4 mmol) was dissolved in 1 M aqueous sodium hydroxide (4 mL) and IMS (5 mL). The mixture was heated by microwave irradiation at 130° C. for 10 minutes, and then filtered. 1 N Hydrochloric acid was added and the resulting precipitate was isolated by filtration washed with water and dried to give the title compound as a white solid (0.15 g). LCMS m/z 205.96 [M+H]+ R.T.=1.51 min. (Analytical Method 5).
後処理
- filtrationfiltered
- addition1 N Hydrochloric acid was added
- customthe resulting precipitate was isolated by filtration
- washwashed with water
- customdried
出典と根拠
- ORDレコード
- ord-736fa6482ddb4aeabbc10a14999bdccf
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08614209B2
反応ノート
読み込み中…