Sodium Hydroxide → 5-(1-methyl-1H-pyrazol-5-yl)-3-thiophenecarboxylic acid

HRID 1914562ノート

反応式

HRID 1914562 の反応式
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([C:10]2[N:11]([CH3:15])[N:12]=[CH:13][CH:14]=2)[S:7][CH:6]=1)=[O:4].[OH-].[Na+]>CO>[CH3:15][N:11]1[C:10]([C:8]2[S:7][CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:9]=2)=[CH:14][CH:13]=[N:12]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 581103165-(2-methyl-2H-pyrazol-3-yl)-thiophene-3-carboxylic acid methyl ester

生成物 1

HCID 581103265-(1-methyl-1H-pyrazol-5-yl)-3-thiophenecarboxylic acid収率 55%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

5-(2-Methyl-2H-pyrazol-3-yl)-thiophene-3-carboxylic acid methyl ester (0.163 g, 073 mmol) was suspended in methanol (1 mL) then sodium hydroxide (1 M, 0.95 mL) was added and the mixture stirred for 2 hours. The solution was evaporated, the residue was taken up in HCl (1 N, 1.5 mL) and the resultant precipitate was collected by filtration and dried in vacuo to afford the title compound as a white solid (0.084 g). LCMS m/z 209.15 [M+H]+ R.T.=2.76 min (Analytical Method 6).

後処理

  1. customThe solution was evaporated
  2. filtrationthe resultant precipitate was collected by filtration
  3. customdried in vacuo

出典と根拠

ORDレコード
ord-54045314cd6d47c2887eb4417b4a24a3
出典データセット
uspto-grants-2013_12
特許番号
US08614209B2

反応ノート

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