Sodium Hydroxide → 5-Oxazol-4-yl-thiophene-3-carboxylic acid

HRID 1914570

反応式

HRID 1914570 の反応式
C[O:2][C:3]([C:5]1[CH:9]=[C:8]([C:10]2[N:11]=[CH:12][O:13][CH:14]=2)[S:7][CH:6]=1)=[O:4].[OH-].[Na+]>>[O:13]1[CH:14]=[C:10]([C:8]2[S:7][CH:6]=[C:5]([C:3]([OH:4])=[O:2])[CH:9]=2)[N:11]=[CH:12]1

参加物

3

反応物 2

HCID 14798Sodium HydroxideHCID 581102445-Oxazol-4-yl-thiophene-3-carboxylic acid methyl ester

生成物 1

HCID 581102215-Oxazol-4-yl-thiophene-3-carboxylic acid収率 100.2%

実験手順

5-Oxazol-4-yl-thiophene-3-carboxylic acid methyl ester (0.049 g, 0.23 mmol) was suspended in IMS (1 mL), sodium hydroxide (1 M, 0.35 mL) was added and the mixture stirred for 60 hours at room temperature. The mixture was quenched with HCl (1 N, 0.35 mL) and then concentrated, azeotroping twice with methanol to afford 5-oxazol-4-yl-thiophene-3-carboxylic acid as a white solid (0.045 g).

後処理

  1. customThe mixture was quenched with HCl (1 N, 0.35 mL)
  2. concentrationconcentrated
  3. customazeotroping twice with methanol

出典と根拠

ORDレコード
ord-c7de7615fddd4f519cf036cba9e59553
出典データセット
uspto-grants-2013_12
特許番号
US08614209B2

関連ノート

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