Hydrazine hydrate (1:1) → HCID 178470478、化合物
反応式
C([O:3][C:4]1[C:5](=O)[CH:6]([C:10](=O)[C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:7][CH2:8][CH:9]=1)C.O.[NH2:19][NH2:20]>C(O)C>[O:3]=[C:4]1[C:5]2[NH:20][N:19]=[C:10]([C:11]([O:13][CH2:14][CH3:15])=[O:12])[C:6]=2[CH2:7][CH2:8][CH2:9]1参加物
4
実験手順
10.0 g (42 mmol) of ethyl (3-ethoxy-2-oxocyclohex-3-en-1-yl)(oxo)acetate were dissolved in 100 mL of ethanol, 2.1 mL of hydrazine hydrate were added and the solution stirred at reflux for one day. The solvent was then evaporated and the residue redissolved with dichloromethane. The organic layer was washed with water, dried over Na2SO4 and concentrated. The crude was triturated with diethyl ether and filtered to give 6.0 g of the title compound (70% yield).
後処理
- temperatureat reflux for one day
- customThe solvent was then evaporated
- dissolutionthe residue redissolved with dichloromethane
- washThe organic layer was washed with water
- dry with materialdried over Na2SO4
- concentrationconcentrated
- customThe crude was triturated with diethyl ether
- filtrationfiltered
出典と根拠
- ORDレコード
- ord-3da0bf00771942eb89d6632dc99a229a
- 出典データセット
- uspto-grants-2013_12
- 特許番号
- US08614220B2
反応ノート
読み込み中…