3,5-Diamino-1,2,4-triazole → HCID 178508251、化合物

HRID 1915597ノート

反応式

HRID 1915597 の反応式
[NH2:1][C:2]1[N:6]=[C:5]([NH2:7])[NH:4][N:3]=1.[C:8]1([CH:14]([C:20](OCC)=[O:21])[C:15](OCC)=[O:16])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>C(N(CCCC)CCCC)CCC>[NH2:1][C:2]1[N:6]=[C:5]2[N:7]=[C:15]([OH:16])[C:14]([C:8]3[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=3)=[C:20]([OH:21])[N:4]2[N:3]=1

参加物

4

反応物 2

HCID 150783,5-Diamino-1,2,4-triazoleHCID 66514Diethyl phenylmalonate

生成物 1

HCID 178508251HCID 178508251、化合物

試薬・触媒・溶媒 1

HCID 7622Tributylamine溶媒

実験手順

A solution of 9.0 g 3,5-diamino-1,2,4-triazole and 22.4 ml diethyl phenylmalonate in N,N-dibutylbutan-1-amine is heated under microwave irradiation to 180° C. for 8 h. The reaction mixture forms two layers after cooling to room temperature. The top layer is removed and the solvent of the lower layer is evaporated. The residue is treated with water and acidified with 5N HCl. The precipitated product is collected by filtration and dried. The crude product is used without further purification.

後処理

  1. customThe top layer is removed
  2. customthe solvent of the lower layer is evaporated
  3. additionThe residue is treated with water
  4. filtrationThe precipitated product is collected by filtration
  5. customdried
  6. customThe crude product is used without further purification

出典と根拠

ORDレコード
ord-0264d4253e5240c2aa2fede970219094
出典データセット
uspto-grants-2013_12
特許番号
US08614218B2

反応ノート

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