Diethyl phenylmalonate → Methyl 5,7-dihydroxy-6-phenylpyrazolo[1,5-a]pyrimidine-2-carboxylate
反応式
[NH2:1][C:2]1[CH:6]=[C:5]([C:7]([O:9][CH3:10])=[O:8])[NH:4][N:3]=1.C([O:13][C:14](=O)[CH:15]([C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=1)[C:16](OCC)=[O:17])C.C(N(C(C)C)CC)(C)C>CN(C=O)C>[OH:13][C:14]1[C:15]([C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][CH:22]=2)=[C:16]([OH:17])[N:3]2[N:4]=[C:5]([C:7]([O:9][CH3:10])=[O:8])[CH:6]=[C:2]2[N:1]=1参加物
5
実験手順
A solution of 5.0 g Methyl 3-amino-1H-pyrazole-5-carboxylate, 8.3 ml diethyl-phenylmalonate and 50 ml diisopropylethylamine in 50 ml DMF is heated to 150° C. for 40 h. The solvent is removed, the solid residue is dissolved in 2-propanol the mixture is stirred for 3 hours. The desired product is filtrated, dried and is used without further purification.