Lithium hydroxide, monohydrate → (s)-2-[4-(2-Fluoro-3-pyrrolidin-1-yl-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid lithium salt

HRID 19158ノート

反応式

HRID 19158 の反応式
C([O:3][C:4](=[O:29])[C@@H:5]([N:10]1[CH2:14][C:13]([O:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([N:22]3[CH2:26][CH2:25][CH2:24][CH2:23]3)[C:17]=2[F:27])=[CH:12][C:11]1=[O:28])[CH2:6][CH:7]([CH3:9])[CH3:8])C.O.[OH-].[Li+:32]>O1CCCC1>[Li+:32].[F:27][C:17]1[C:18]([N:22]2[CH2:23][CH2:24][CH2:25][CH2:26]2)=[CH:19][CH:20]=[CH:21][C:16]=1[O:15][C:13]1[CH2:14][N:10]([C@@H:5]([CH2:6][CH:7]([CH3:9])[CH3:8])[C:4]([O-:29])=[O:3])[C:11](=[O:28])[CH:12]=1

参加物

4

反応物 2

HCID 168937Lithium hydroxide, monohydrateHCID 66894784(S)-2-[4-(2-fluoro-3-pyrrolidin-1-yl-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid ethyl ester

生成物 1

HCID 67503794(s)-2-[4-(2-Fluoro-3-pyrrolidin-1-yl-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid lithium salt収率 126.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
25 °C

実験手順

To a solution containing (S)-2-[4-(2-fluoro-3-pyrrolidin-1-yl-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid ethyl ester (0.120 g, 0.29 mmol) in tetrahydrofuran (4 mL) was treated with an aqueous solution of lithium hydroxide monohydrate (0.5N, 1.2 mL, 0.6 mmol). The mixture was stirred at 25° C. for 2 h, and the solvents evaporated. The residue was rinsed with diethyl ether which afforded (S)-2-[4-(2-fluoro-3-pyrrolidin-1-yl-phenoxy)-2-oxo-2,5-dihydro-pyrrol-1-yl]-4-methyl-pentanoic acid lithium salt (0.140 g, 100%) as a yellow solid.

後処理

  1. customthe solvents evaporated
  2. washThe residue was rinsed with diethyl ether which

出典と根拠

ORDレコード
ord-1975987fe34a4f76bffb36371302f57d
出典データセット
uspto-grants-2010_06
特許番号
US07741327B2

反応ノート

読み込み中…