Acetic Acid → 1-(2-Fluoro-3-hydroxyphenyl)ethanone

HRID 19160ノート

反応式

HRID 19160 の反応式
[C:1]([C:4]1[C:5]([F:13])=[C:6](B(O)O)[CH:7]=[CH:8][CH:9]=1)(=[O:3])[CH3:2].C(O)(=[O:16])C.OO>O1CCCC1>[F:13][C:5]1[C:6]([OH:16])=[CH:7][CH:8]=[CH:9][C:4]=1[C:1](=[O:3])[CH3:2]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 784Hydrogen PeroxideHCID 16217905(3-Acetyl-2-fluorophenyl)boronic acid

生成物 1

HCID 668947801-(2-Fluoro-3-hydroxyphenyl)ethanone収率 100%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

To a solution of (3-acetyl-2-fluorophenyl)boronic acid (10.0 g, 0.055 mol) in tetrahydrofuran (160 mL) was added glacial acetic acid (60 mL). The resulting mixture was cooled to 0° C. before hydrogen peroxide (50% aqueous solution, 8 mL) was added. The resulting mixture was allowed to come to room temperature and stirred for 5 h. The mixture was evaporated and the residue was dissolved in ethyl acetate, washed with hydrochloric acid (0.5N), water and brine. The organic phase was dried, filtered and evaporated which afforded 1-(2-fluoro-3-hydroxy-phenyl)-ethanone (8.50 g, 100%) as a white solid.

後処理

  1. additionwas added
  2. customto come to room temperature
  3. customThe mixture was evaporated
  4. dissolutionthe residue was dissolved in ethyl acetate
  5. washwashed with hydrochloric acid (0.5N), water and brine
  6. customThe organic phase was dried
  7. filtrationfiltered
  8. customevaporated which

出典と根拠

ORDレコード
ord-24a4464aef7f4202ae29151c30171f4a
出典データセット
uspto-grants-2010_06
特許番号
US07741327B2

反応ノート

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