Formamide → HCID 178497210、化合物
反応式
[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([C:9]([C:15]([O:17]CC)=O)=[C:10]([NH2:14])[NH:11]2)=[CH:7][CH:6]=1)=[O:4].C([O-])=O.[NH4+].O.[CH:25]([NH2:27])=O>>[CH3:1][O:2][C:3]([C:5]1[CH:13]=[C:12]2[C:8]([C:9]3[C:15]([OH:17])=[N:27][CH:25]=[N:14][C:10]=3[NH:11]2)=[CH:7][CH:6]=1)=[O:4]参加物
5
反応条件
- 温度
- 170 °C
実験手順
A suspension of 2-amino-1H-indole-3,6-dicarboxylic acid 3-ethyl ester 6-methyl ester (259 mg, 1 mmol) and ammonium formate (62 mg, 1 mmol) in 2 mL formamide was heated under an atmosphere of nitrogen to 170° C. overnight. On cooling to room temperature, water was added and the resulting precipitate was collected by filtration and dried in a vacuum oven for 4 hours to a constant weight to give the title compound (103 mg, 0.42 mmol). LC-MS (1) Rt 1.27 min; m/z (ES−) 242.