Ethanolamine → N-(2-Hydroxyethyl)-2,2-dimethylpropanamide

HRID 1916342ノート

反応式

HRID 1916342 の反応式
[CH2:1]([CH2:3][NH2:4])[OH:2].[OH-].[K+].[C:7](Cl)(=[O:12])[C:8]([CH3:11])([CH3:10])[CH3:9]>O>[OH:2][CH2:1][CH2:3][NH:4][C:7](=[O:12])[C:8]([CH3:11])([CH3:10])[CH3:9]

参加物

5

反応物 3

HCID 700EthanolamineHCID 14797Potassium HydroxideHCID 62493Pivaloyl chloride

生成物 1

HCID 15074197N-(2-Hydroxyethyl)-2,2-dimethylpropanamide収率 50.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

To a stirred 4° aqueous solution containing ethanolamine (610 mg, 10 mmol), KOH (840 mg, 15 mmol) and H2O (15 mL) was added pivaloyl chloride (1.44 g, 12 mmol) whereupon the reaction was allowed to slowly warm to 20°. After stirring for 18 hr, the solution was extracted 4× with EtOAc,. The combined organic layers were washed with brine, dried over Na2SO4 prior to concentration using a rotary evaporator to yield 737 mg of a clear oil.

後処理

  1. temperatureto slowly warm to 20°
  2. extractionthe solution was extracted 4× with EtOAc
  3. washThe combined organic layers were washed with brine
  4. dry with materialdried over Na2SO4
  5. concentrationto concentration
  6. customa rotary evaporator

出典と根拠

ORDレコード
ord-eb83732cd0b04f12ab314b4768a224b3
出典データセット
uspto-grants-2013_12
特許番号
US08618115B2

反応ノート

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