Tetrabutylammonium Fluoride → 2-(5-Ethynyl-indol-1-yl)-ethanol

HRID 1916708ノート

反応式

HRID 1916708 の反応式
CCCC[N+](CCCC)(CCCC)CCCC.[F-].C[Si]([C:23]#[C:24][C:25]1[CH:26]=[C:27]2[C:31](=[CH:32][CH:33]=1)[N:30]([CH2:34][CH2:35][OH:36])[CH:29]=[CH:28]2)(C)C>C1COCC1>[C:24]([C:25]1[CH:26]=[C:27]2[C:31](=[CH:32][CH:33]=1)[N:30]([CH2:34][CH2:35][OH:36])[CH:29]=[CH:28]2)#[CH:23]

参加物

4

反応物 2

HCID 2724141Tetrabutylammonium FluorideHCID 673645732-(5-Trimethylsilanylethynyl-indol-1-yl)-ethanol

生成物 1

HCID 859695012-(5-Ethynyl-indol-1-yl)-ethanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

実験手順

Under an N2 atmosphere 29 g (91.8 mmol) TBAF are added to a solution of 21.5 g (83.5 mmol) 2-(5-trimethylsilanylethynyl-indol-1-yl)-ethanol in 500 mL THF and the reaction mixture is stirred for 1.5 h at RT. The mixture is evaporated down i. vac., the residue is taken up in 300 mL EtOAc, the organic phase is washed twice with in each case 200 mL water and once with 200 mL saturated NaCl solution and dried over Na2SO4. After the desiccant and solvent have been eliminated the desired product is obtained in the form of a brown oil.

後処理

  1. customThe mixture is evaporated down i
  2. washthe organic phase is washed twice with in each case 200 mL water and once with 200 mL saturated NaCl solution
  3. dry with materialdried over Na2SO4
  4. customis obtained in the form of a brown oil

出典と根拠

ORDレコード
ord-1c132bf5bf4e456192c1a58216ac499e
出典データセット
uspto-grants-2013_12
特許番号
US08618132B2

反応ノート

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