Potassium Carbonate → 5-Bromo-2-pyrrolidin-1-ylmethyl-benzoxazole

HRID 1916761ノート

反応式

HRID 1916761 の反応式
[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10]Cl)=[N:7][C:6]=2[CH:12]=1.C([O-])([O-])=O.[K+].[K+].[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1>CN(C=O)C.O>[Br:1][C:2]1[CH:3]=[CH:4][C:5]2[O:9][C:8]([CH2:10][N:19]3[CH2:23][CH2:22][CH2:21][CH2:20]3)=[N:7][C:6]=2[CH:12]=1

参加物

6

反応物 3

HCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 142042085-Bromo-2-(chloromethyl)-1,3-benzoxazole

生成物 1

HCID 673655735-Bromo-2-pyrrolidin-1-ylmethyl-benzoxazole

試薬・触媒・溶媒 2

HCID 962Water溶媒HCID 6228Dimethylformamide溶媒

実験手順

A solution of 2 g (8.11 mmol) 5-bromo-2-chloromethyl-benzoxazole in 30 mL DMF is combined with 2.24 g (16.22 mmol) K2CO3 and 0.9 mL (10.78 mmol) pyrrolidine and stirred for 24 hours at RT. The reaction mixture is diluted with water and extracted with EtOAc. The organic phase is dried over Na2SO4, the desiccant is filtered off and the filtrate is evaporated down.

後処理

  1. extractionextracted with EtOAc
  2. dry with materialThe organic phase is dried over Na2SO4
  3. filtrationthe desiccant is filtered off
  4. customthe filtrate is evaporated down

出典と根拠

ORDレコード
ord-60132da22cba45ec88c52177cc03b648
出典データセット
uspto-grants-2013_12
特許番号
US08618132B2

反応ノート

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