Methyl chloroformate → Methyl 2-(4-methoxyphenylthio)ethylcarbamate

HRID 1917062ノート

反応式

HRID 1917062 の反応式
Cl.[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10][CH2:11][CH2:12][NH2:13])=[CH:6][CH:5]=1.Cl[C:15]([O:17][CH3:18])=[O:16].C(N(CC)CC)C>C(Cl)Cl>[CH3:2][O:3][C:4]1[CH:9]=[CH:8][C:7]([S:10][CH2:11][CH2:12][NH:13][C:15](=[O:16])[O:17][CH3:18])=[CH:6][CH:5]=1

参加物

5

反応物 3

HCID 6586Methyl chloroformateHCID 8471TriethylamineHCID 122619332-(4-Methoxyphenylthio)ethanamine hydrochloride

生成物 1

HCID 57864658Methyl 2-(4-methoxyphenylthio)ethylcarbamate

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

反応条件

温度
0 °C

実験手順

To a solution of compound 1-HCl (0.466 g) in CH2Cl2 (20 mL) cooled to ˜0° C. was added methyl chloroformate (1.1 eq.) and triethylamine (2.5 eq.). The reaction mixture was stirred for 2 hours at 0° C. and washed with 1N HCl, and sat. NaHCO3. The solvents were removed by evaporation under reduced pressure to give product 7 as white solid with a yield of 480 mg, 98%.

後処理

  1. washwashed with 1N HCl, and sat. NaHCO3
  2. customThe solvents were removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-8750feda5c6a4ea29967aef840d837b7
出典データセット
uspto-grants-2013_12
特許番号
US08618282B2

反応ノート

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