Diisopropylethylamine → HCID 68089233、化合物
反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:32])[N:10]([C@:12]2([CH3:31])[C@@H:16]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)[CH2:15][N:14](CC3C=CC=CC=3)[CH2:13]2)[CH3:11])=[CH:4][CH:3]=1.CCN(C(C)C)C(C)C.ClC(OC(Cl)C)=O>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][C:9](=[O:32])[N:10]([C@:12]2([CH3:31])[C@@H:16]([C:17]3[CH:22]=[CH:21][C:20]([Cl:23])=[CH:19][CH:18]=3)[CH2:15][NH:14][CH2:13]2)[CH3:11])=[CH:4][CH:3]=1参加物
5
実験手順
A mixture of 1.65 g (3.64 mmol) rac-[(3R,4S)-1-Benzyl-4-(4-chloro-phenyl)-3-methyl-pyrrolidin-3-yl]-methyl-carbamic acid 4-fluoro-phenyl ester, 0.75 g (5.83 mmol) DIPEA and 0.78 g (5.46 mmol) 1-chloroethyl chloroformate in 40 mL toluene was stirred at room temperature and evaporated to dryness. The residue was taken up in 40 mL methanol and stirred for 2 h at room temperature and evaporated to dryness to yield the crude title compound which was used without further purification in the consecutive step.