L-Malic Acid → Sunitinib Malate

HRID 1918243

反応式

HRID 1918243 の反応式
[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[C:30]([OH:38])(=[O:37])[C@H:31]([CH2:33][C:34]([OH:36])=[O:35])[OH:32]>CCOC(C)=O>[CH3:1][CH2:2][N:3]([CH2:6][CH2:7][NH:8][C:9]([C:11]1[C:15]([CH3:16])=[C:14](/[CH:17]=[C:18]2/[C:19]3[CH:24]=[C:23]([F:25])[CH:22]=[CH:21][C:20]=3[NH:26][C:27]/2=[O:28])[NH:13][C:12]=1[CH3:29])=[O:10])[CH2:4][CH3:5].[CH2:33]([C:34]([OH:36])=[O:35])[C@H:31]([OH:32])[C:30]([OH:38])=[O:37]

参加物

4

反応物 2

HCID 222656L-Malic AcidHCID 5329102Sunitinib

生成物 1

HCID 6456015Sunitinib Malate

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

To Sunitinib base (300 mg), L-malic acid (101 mg), and AcOEt (10 ml) are added, the mixture is heated to 77 C for 10 min, after precipitation the obtained solid is filtered, dried on air.

後処理

  1. temperaturethe mixture is heated to 77 C for 10 min
  2. customafter precipitation the obtained solid
  3. filtrationis filtered
  4. customdried on air

出典と根拠

ORDレコード
ord-05ef6dc551c142de985b740b30c151e9
出典データセット
uspto-grants-2013_12
特許番号
US08618309B2

関連ノート

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