Sodium Hydroxide → 4-Oxetan-3-yl-3-(2-m-tolyl-ethoxy)-benzoic Acid

HRID 1918333ノート

反応式

HRID 1918333 の反応式
C([O:4][C:5](=[O:26])[C:6]1[CH:11]=[CH:10][C:9]([CH:12]2[CH2:15][O:14][CH2:13]2)=[C:8]([O:16][CH2:17][CH2:18][C:19]2[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=2)[CH:7]=1)(C)C.[OH-].[Na+]>CO>[O:14]1[CH2:15][CH:12]([C:9]2[CH:10]=[CH:11][C:6]([C:5]([OH:26])=[O:4])=[CH:7][C:8]=2[O:16][CH2:17][CH2:18][C:19]2[CH:20]=[C:21]([CH3:25])[CH:22]=[CH:23][CH:24]=2)[CH2:13]1

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 671701384-Oxetan-3-yl-3-(2-m-tolyl-ethoxy)-benzoic Acid Isopropyl Ester

生成物 1

HCID 671687094-Oxetan-3-yl-3-(2-m-tolyl-ethoxy)-benzoic Acid収率 99.3%

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

120 mg of 4-oxetan-3-yl-3-(2-m-tolyl-ethoxy)-benzoic acid isopropyl ester were dissolved in 3 ml of methanol and 0.2 ml of a 2 N aqueous solution of sodium hydroxide added. The mixture was left at room temperature for 6 days and then evaporated. The residue was dissolved in 10 ml of water, the pH adjusted to 2 with an aqueous sodium hydrogensulfate solution, and the mixture extracted three times using 20 ml each of DCM. The combined extracts were dried with magnesium sulfate and evaporated to yield 105 mg of the title compound.

後処理

  1. customevaporated
  2. dissolutionThe residue was dissolved in 10 ml of water
  3. extractionthe mixture extracted three times
  4. dry with materialThe combined extracts were dried with magnesium sulfate
  5. customevaporated

出典と根拠

ORDレコード
ord-c8d2e2a4461d48e29d093d79975bbc1f
出典データセット
uspto-grants-2013_12
特許番号
US08618304B2

反応ノート

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