(S)-5-(3-nitro-pyrazol-1-ylmethyl)-oxazolidin-2-one → HCID 66893932、化合物

HRID 19188ノート

反応式

HRID 19188 の反応式
[N+:1]([C:4]1[CH:8]=[CH:7][N:6]([CH2:9][C@H:10]2[O:14][C:13](=[O:15])[NH:12][CH2:11]2)[N:5]=1)([O-])=O.[H][H]>[Pd].C(O)C>[NH2:1][C:4]1[CH:8]=[CH:7][N:6]([CH2:9][C@H:10]2[O:14][C:13](=[O:15])[NH:12][CH2:11]2)[N:5]=1

参加物

5

反応物 2

HCID 66895029(S)-5-(3-nitro-pyrazol-1-ylmethyl)-oxazolidin-2-oneHCID 178418361HCID 178418361、化合物

生成物 1

HCID 66893932HCID 66893932、化合物収率 91%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

In a Parr shaker bottle was placed (S)-5-(3-nitro-pyrazol-1-ylmethyl)-oxazolidin-2-one (364 mg, 1.72 mmol), 10% palladium on carbon (200 mg) and ethanol (25 mL). The bottle was then placed on the Parr shaker at 50 psi of hydrogen pressure for 4 h. The reaction was then filtered through a pad of celite and washed with ethanol and concentrated in vacuo to afford (S)-5-(3-amino-pyrazol-1-ylmethyl)-oxazolidin-2-one (3.60 mg, 91%) as a yellow oil: LR-ES-MS m/z calculated for C7H10N4O2 [M]+ 182, observed 183 [M+H]+.

後処理

  1. filtrationThe reaction was then filtered through a pad of celite
  2. washwashed with ethanol
  3. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-90d1bdc1f86245ca90ed5555c7b442ea
出典データセット
uspto-grants-2010_06
特許番号
US07741327B2

反応ノート

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