N-bromobutanimide → 2-(Bromomethyl)-5-(2'-methoxy-5'-fluorophenyl)tetrahydrofuran
反応式
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([F:9])=[CH:5][C:4]=1[CH:10]([OH:15])[CH2:11][CH2:12][CH:13]=[CH2:14].[Br:16]N1C(=O)CCC1=O>C(Cl)Cl>[Br:16][CH2:14][CH:13]1[CH2:12][CH2:11][CH:10]([C:4]2[CH:5]=[C:6]([F:9])[CH:7]=[CH:8][C:3]=2[O:2][CH3:1])[O:15]1参加物
4
実験手順
To a solution of 1-(2′-methoxy-5′-fluorophenyl)pent-4-en-1-ol (3.24 g, 18.0 mmol) in dry CH2Cl2 (50 mL) at 0° C. was added portionwise N-bromosuccinimide (NBS, 3.56 g, 20.0 mmol) portionwise and the reaction was warmed to room temperature for 12 h. Solvent was then removed in vacuo and the residue was purified by flash column chromatography (10% EtOAc in Hexane, Rf=0.28) to give the product (2.28 g, 44%) as an oil.
後処理
- customSolvent was then removed in vacuo
- customthe residue was purified by flash column chromatography (10% EtOAc in Hexane, Rf=0.28)
出典と根拠
- ORDレコード
- ord-5cf6613acdeb4b2ab32af2cda0136a6e
- 出典データセット
- uspto-grants-2012_05
- 特許番号
- US08168635B2
反応ノート
読み込み中…