Ethyl-3-(5'-fluoro-2'-methoxybenzyl)acrylate → Ethyl-4-(5'-fluoro-2'-methoxyphenyl)butyrate
反応式
[CH2:1]([O:3][C:4](=[O:17])[CH:5]=[CH:6][CH2:7][C:8]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:9]=1[O:15][CH3:16])[CH3:2]>C(O)C.[Pd]>[CH2:1]([O:3][C:4](=[O:17])[CH2:5][CH2:6][CH2:7][C:8]1[CH:13]=[C:12]([F:14])[CH:11]=[CH:10][C:9]=1[O:15][CH3:16])[CH3:2]参加物
4
実験手順
To a solution of ethyl-3-(5′-fluoro-2′-methoxybenzyl)acrylate (2.36 g, 10.0 mmol) in ethanol (100%, 40 mL) under Ar(g) was added Pd/C (10%, 200 mg) very carefully and the flask containing the mixture was evacuated and purged with H2 three time each. Then a balloon was attached to the flask and the reaction was allowed to go for 15 h at room temperature. The reaction mixture was filtered through a pad of silica eluted with mixed solvent of EtOAc and Hexane (1:1). The crude product that obtained by removal of the solvent in vacuo was purified by a flash column chromatography (10% EtOAc in hexane, Rf=0.20) to give the product (2.25 g, 95%).