HCID 59226578、化合物 → (4R)-4-(hydroxymethyl)-5-(1-hydroxypropan-2-yl)oxazolidin-2-one

HRID 1920229ノート

反応式

HRID 1920229 の反応式
C([O:8][CH2:9][C@@H:10]1[CH:14]([CH:15]([CH3:18])[CH2:16][OH:17])[O:13][C:12](=[O:19])[NH:11]1)C1C=CC=CC=1>CO.[Pd]>[OH:8][CH2:9][C@@H:10]1[CH:14]([CH:15]([CH3:18])[CH2:16][OH:17])[O:13][C:12](=[O:19])[NH:11]1

参加物

4

反応物 1

HCID 59226578HCID 59226578、化合物

生成物 1

HCID 59226593(4R)-4-(hydroxymethyl)-5-(1-hydroxypropan-2-yl)oxazolidin-2-one収率 99%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

To a solution of (4R)-4-(benzyloxymethyl)-5-(1-hydroxypropan-2-yl)oxazolidin-2-one (1.0 equiv.) in methanol, at a concentration of 0.1 M, was added 10% palladium on carbon (0.1 eq.). The resultant heterogeneous solution was put under an atmosphere of hydrogen and was stirred for 15 hours. At this time the mixture was filtered through a pad of celite eluting with methanol. The volatiles were removed in vacuo yielding (4R)-4-(hydroxymethyl)-5-(1-hydroxypropan-2-yl)oxazolidin-2-one (99%). LCMS (m/z): 176.1 (MH+).

後処理

  1. filtrationAt this time the mixture was filtered through a pad of celite
  2. washeluting with methanol
  3. customThe volatiles were removed in vacuo

出典と根拠

ORDレコード
ord-c04e460418be4249b46c404264e1ce09
出典データセット
uspto-grants-2012_05
特許番号
US08168794B2

反応ノート

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